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Research

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Research

The Science Behind Wellness Labs J&A

At Wellness Labs J&A, we believe supplements should be built on more than marketing—they should be grounded in rigorous scientific research. Every capsule, every ingredient, is selected because it is supported by evidence, tested for safety, and formulated for results.

Here, we present the science behind three of our core supplements:

  • NAD⁺ & Nicotinamide Riboside (NR)

  • Magnesium Dual Complex (Citrate + Glycinate)

  • Curcumin (Turmeric Extract)

1. NAD⁺ & Nicotinamide Riboside (NR): Cellular Energy & Longevity

Why NAD⁺ matters

NAD⁺ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell. It:

  • Powers ATP energy production in mitochondria

  • Activates sirtuins (enzymes for DNA repair & longevity)

  • Supports oxidative stress balance and immune function

With age, NAD⁺ levels decline—up to 50% by middle age—contributing to fatigue, metabolic disorders, neurodegeneration, and accelerated aging.

The role of NR

Nicotinamide riboside (NR) is a next-generation NAD⁺ precursor. Unlike traditional niacin, NR:

  • Safely and rapidly increases NAD⁺

  • Improves mitochondrial efficiency

  • Shows benefits for metabolism, cardiovascular health, and brain function

Clinical evidence

  • NR supplementation raised NAD⁺ by 22–142% depending on dose over 8 weeks, with excellent safety (Trammell et al., 2019).

  • In older adults, NR led to a 90% NAD⁺ increase with improvements in energy metabolism (Dellinger et al., 2018).

  • A 2023 trial in Parkinson’s patients showed 5-fold NAD⁺ increases with symptom improvement (Brakedal et al., 2023).

  • Cardiometabolic studies suggest NR supports lipid metabolism and vascular health (JACC, 2022).

Summary: NR supplementation restores cellular energy and resilience, supporting healthy aging from within.

2. Magnesium Dual Complex (Citrate + Glycinate): Essential Mineral Support

Why magnesium matters

Magnesium is a cofactor for over 300 enzymes and is crucial for:

  • Energy production

  • Muscle contraction & relaxation

  • Nervous system balance

  • Cardiovascular regulation

  • Bone and DNA health

Deficiency affects up to half of adults worldwide, leading to fatigue, cramps, poor sleep, anxiety, and higher cardiovascular risk.

Why combine citrate + glycinate?

  • Citrate: Fast absorption, supports muscles and digestion.

  • Glycinate: Bound to glycine → high bioavailability, gentle on the stomach, promotes calm and better sleep.

The combination delivers both rapid uptake and sustained nervous system support.

Clinical evidence

  • Magnesium glycinate offers superior absorption and tolerance compared to other forms (Verywell Health, 2023).

  • Supplementation improves sleep quality, muscle recovery, and stress resilience.

  • Higher magnesium intake is associated with lower blood pressure and cardiovascular risk (Fang et al., 2016, BMJ).

Summary: Our Magnesium Dual Complex restores balance, supporting muscle, sleep, stress, and heart health with optimal absorption.

3. Curcumin (Turmeric Extract): Natural Inflammation Defense

Why inflammation matters

Chronic low-grade inflammation is a key driver of:

  • Joint pain & arthritis

  • Cardiovascular disease

  • Diabetes & metabolic syndrome

  • Cognitive decline

How curcumin works

Curcumin, the active compound in turmeric, is a potent anti-inflammatory and antioxidant that:

  • Inhibits NF-κB, a master regulator of inflammation

  • Reduces oxidative stress

  • Supports joint mobility

  • Promotes brain health via BDNF (brain-derived neurotrophic factor)

Clinical evidence

  • Meta-analysis of 21 RCTs: curcumin significantly reduces joint pain and improves function (Daily et al., 2023).

  • Review in ACS Pharmacology: benefits for oxidative stress, metabolic health, and inflammation-driven conditions (Panahi et al., 2023).

  • Scoping review: curcumin showed positive health outcomes in ~75% of clinical studies across multiple systems (Yuan et al., 2023).

Summary: Curcumin is one of the best-researched natural compounds for supporting joint health, cardiovascular function, and long-term vitality.

✅ The Wellness Labs J&A Commitment

Backed by Science – Every formula is based on human clinical evidence. Optimized for Absorption – Only premium, bioavailable forms of nutrients. Clean & Transparent – No fillers, no gimmicks, just what works. Passion for Results – Our mission is helping people feel stronger, younger, and more energized.

📚 References


NAD⁺ & NR

  • Brakedal, B., et al. (2023). Nicotinamide riboside supplementation increases NAD+ in Parkinson’s disease: A randomized clinical trial. Nature Communications. PubMed

  • Dellinger, R. W., et al. (2018). Nicotinamide riboside increases NAD+ in older adults. Nature Communications. PubMed

  • Trammell, S. A., et al. (2019). Nicotinamide riboside increases NAD+ in humans safely. npj Aging and Mechanisms of Disease. PubMed

  • JACC Review (2022). NAD+ metabolism and cardiometabolic health. Journal of the American College of Cardiology. Link

Magnesium

  • Fang, X., et al. (2016). Dietary magnesium intake and risk of cardiovascular disease: A meta-analysis. BMJ. PubMed

  • Verywell Health. (2023). Magnesium Glycinate vs Citrate: Benefits and Differences. Link

Curcumin

  • Daily, J. W., et al. (2023). Curcumin supplementation improves joint pain and function: A meta-analysis of RCTs. Journal of Medicinal Food. PubMed

  • Panahi, Y., et al. (2023). Curcumin in chronic inflammation and metabolic health. ACS Pharmacology & Translational Science. ACS

  • Yuan, H., et al. (2023). Clinical trials of curcumin: A scoping review. Frontiers in Pharmacology. PubMed